John B Holcomb Selected Research

Ligation

1/2018	Plasma Resuscitation Improved Survival in a Cecal Ligation and Puncture Rat Model of Sepsis.
12/2017	The trauma center is too late: Major limb trauma without a pre-hospital tourniquet has increased death from hemorrhagic shock.
11/2016	Safety and Appropriateness of Tourniquets in 105 Civilians.
11/2005	Complications of nonoperative management of high-grade blunt hepatic injuries.

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John B Holcomb Research Topics

Disease

245	Wounds and Injuries (Trauma) 11/2022 - 01/2002
125	Hemorrhage 01/2022 - 06/2002
41	Hemorrhagic Shock 01/2022 - 07/2003
31	Shock 02/2022 - 12/2002
19	Burns 01/2020 - 03/2005
17	Acidosis 01/2020 - 05/2005
16	Hypothermia 01/2019 - 05/2005
10	Hypotension (Low Blood Pressure) 12/2020 - 07/2003
10	Sepsis (Septicemia) 01/2019 - 11/2005
10	Vascular System Injuries 12/2017 - 01/2007
9	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2022 - 09/2006
8	Infections 06/2016 - 05/2006
7	Multiple Trauma (Multiple Injuries) 01/2018 - 06/2005
6	Ischemia 01/2020 - 01/2004
6	Pain (Aches) 12/2019 - 08/2004
6	Abdominal Injuries 01/2018 - 05/2003
5	Exsanguination 02/2022 - 10/2005
5	Inflammation (Inflammations) 01/2020 - 01/2011
5	Pneumothorax 08/2018 - 06/2007
5	Traumatic Amputation (Traumatic Amputations) 12/2017 - 02/2008
5	Critical Illness (Critically Ill) 11/2016 - 08/2009
5	Edema (Dropsy) 01/2016 - 05/2010
5	Lung Injury 06/2011 - 04/2003
4	Thrombosis (Thrombus) 04/2021 - 11/2006
4	Venous Thromboembolism 01/2021 - 01/2011
4	Acute Lung Injury 01/2018 - 10/2010
4	Paralysis (Palsy) 11/2016 - 02/2008
4	Compartment Syndromes 11/2016 - 02/2008
4	Multiple Organ Failure (MODS) 06/2012 - 05/2003
4	Hypovolemia 01/2010 - 09/2006
4	Hemophilia A (Haemophilia) 06/2008 - 08/2002
4	Intra-Abdominal Hypertension 02/2008 - 12/2002
3	Craniocerebral Trauma (Head Injury) 03/2022 - 09/2006
3	Nonpenetrating Wounds 01/2022 - 01/2018
3	Stroke (Strokes) 01/2022 - 07/2012
3	Thrombophilia 01/2019 - 07/2014
3	Thoracic Injuries (Chest Injury) 01/2018 - 07/2011
3	Tics (Tic) 01/2018 - 03/2014
3	Soft Tissue Injuries (Soft Tissue Injury) 12/2017 - 11/2016
3	Surgical Wound Infection 01/2017 - 03/2016
3	Acute Kidney Injury (Acute Renal Failure) 11/2016 - 02/2008
3	Brain Injuries (Brain Injury) 10/2016 - 08/2011

Drug/Important Bio-Agent (IBA)

41	Hemostatics (Antihemorrhagics)IBA 01/2021 - 06/2002
22	recombinant FVIIa (rFVIIa)FDA Link 07/2011 - 08/2002
16	Hemoglobins (Hemoglobin)IBA 10/2021 - 04/2009
15	Fibrinogen (Factor I)FDA Link 01/2020 - 11/2005
14	Crystalloid SolutionsIBA 01/2018 - 12/2002
14	Factor VIIa (Activated Factor VII)IBA 07/2011 - 08/2004
12	Thrombin FDA Link 01/2022 - 05/2005
9	Ringer's LactateIBA 01/2021 - 05/2003
9	Blood Coagulation Factors (Coagulation Factor)IBA 04/2016 - 06/2007
8	Syndecan-1 (Syndecan 1)IBA 12/2018 - 01/2011
7	Explosive Agents (Explosives)IBA 01/2014 - 05/2006
6	Tranexamic Acid (AMCA)FDA Link 01/2020 - 04/2011
6	Colloids (Colloid)IBA 01/2016 - 05/2008
5	Biomarkers (Surrogate Marker)IBA 03/2022 - 12/2017
5	Interleukin-6 (Interleukin 6)IBA 01/2021 - 07/2003
5	salicylhydroxamic acid (SHAM)IBA 01/2021 - 07/2003
5	Lactic Acid (Lactate)FDA LinkGeneric 01/2018 - 01/2004
5	Pharmaceutical PreparationsIBA 06/2016 - 08/2002
4	SolutionsIBA 12/2021 - 05/2008
4	Anti-Bacterial Agents (Antibiotics)IBA 11/2018 - 12/2006
4	Insulin (Novolin)FDA Link 02/2010 - 12/2007
4	Glucose (Dextrose)FDA LinkGeneric 02/2010 - 12/2007
4	Fibrin Tissue Adhesive (Fibrin Sealant)IBA 01/2007 - 06/2002
3	CytokinesIBA 01/2021 - 07/2003
3	butyl phosphorotrithioate (DEF)IBA 01/2021 - 01/2018
3	ElementsIBA 01/2021 - 12/2008
3	Interleukin-8 (Interleukin 8)IBA 01/2021 - 02/2008
3	FibrinIBA 01/2020 - 02/2003
3	AnticoagulantsIBA 01/2018 - 04/2009
3	Biological ProductsIBA 01/2017 - 01/2008
3	Proteins (Proteins, Gene)FDA Link 01/2016 - 01/2011
3	Dihydrotachysterol (AT 10)IBA 05/2015 - 07/2013
3	Antifibrinolytic Agents (Antifibrinolytics)IBA 12/2014 - 02/2010

Therapy/Procedure

128	Resuscitation 01/2022 - 01/2002
31	Therapeutics 11/2021 - 03/2002
27	Laparotomy 01/2022 - 11/2005
23	Tourniquets 02/2022 - 10/2005
18	Blood Transfusion (Blood Transfusions) 11/2022 - 05/2007
14	Critical Care (Surgical Intensive Care) 10/2017 - 01/2004
10	Length of Stay 01/2019 - 04/2003
9	Surgical Amputation (Amputations) 09/2017 - 01/2008
8	Thoracotomy 01/2022 - 10/2015
8	Mechanical Ventilators (Ventilator) 01/2018 - 04/2003
6	Erythrocyte Transfusion 01/2019 - 02/2008
6	Sutures (Suture) 01/2018 - 06/2002
6	Hemodilution 10/2013 - 06/2007
5	Catheters 01/2020 - 08/2004
5	Platelet Transfusion (Blood Platelet Transfusions) 01/2018 - 11/2010
5	Artificial Respiration (Mechanical Ventilation) 11/2016 - 07/2010
4	Ligation 01/2018 - 11/2005
4	Cardiopulmonary Resuscitation (CPR) 01/2018 - 10/2008
4	Lower Body Negative Pressure 04/2008 - 12/2002
3	MT protocol 01/2021 - 06/2010
3	Induced Hypothermia 01/2020 - 01/2009
3	Thoracostomy 08/2018 - 01/2009
3	Decompression 08/2018 - 10/2008
3	Fluid Therapy (Oral Rehydration Therapy) 06/2017 - 01/2016
3	Limb Salvage 01/2016 - 04/2009